It's summertime and the usual gang, Fabio, Chicho, and RS reunite. This time Fabio suffers from "persécolis" a psychological illness that makes him think that he is being constantly followed. Tired of this situation, his friends decide to take him to a "naturopath." A very peculiar doctor, Charles Manson established on the exotic Puerto Rican Island of Culebra, where goofing around is the norm. On their trip they go through a series of uncanny and fun adventures, meet Amanda and her friends, and end up discovering that they have grown up and that responsibility has caught up with their merry lives, which will make this final summer and unforgettable one.